Side Effect: Loss of Pigmentation (Vitiligo)

What is Loss of Pigmentation (Vitiligo)?

What does Loss of Pigmentation (Vitiligo) look like?

Vitiligo typically appears as depigmented patches of skin on the face, arms, hands, and other areas where there is friction to the skin. The patches can vary in size and shape and may appear as sharply defined borders or gradually fade into the surrounding skin.

Who gets Loss of Pigmentation (Vitiligo)?

• Vitiligo is the most common skin pigmentation disorder and affects 0.5-2% of people worldwide.
  
  
• Patients with cancer may develop vitiligo as a side effect of certain chemotherapy and immunotherapy treatments.
  
  
• Vitilgo may occur in as many 25% (one out of every 4 people) of patients receiving immunotherapy treatments. With immunotherapy treatments, vitiligo may not appear until months after starting treatment. The appearance of vitiligo has been linked with better treatment response in some cancers such as melanoma.

How to treat Loss of Pigmentation (Vitiligo)

The treatment of vitiligo in cancer patients can be challenging as it does not usually resolve after stopping the causative treatments and certain treatments for vitiligo may be contraindicated.

In general, it is recommended to avoid exposure to sunlight and to keep affected areas covered. Topical treatments that decrase the immune system response, such as hydrocortisone (a corticosteroid), may used but only after approved by your doctor. If appropriate, alternative treatments that may be considered include phototherapy, systemic corticosteroids (such as prednisone pills), surgical grafting, or depigmentation treatments.