Side Effect: Motor Neuropathy (damage to nerves controlling muscles)

What is Motor Neuropathy (damage to nerves controlling muscles)?

Nerves that control muscles and movement are known as motor neurons. These neurons are located in the brain and spinal cord. When these nerves are injured or damaged, this can lead to muscle weakness, atrophy (muscles that shrink in size), impaired movement, and potentially paralysis (inability to move certain muscles).

What does Motor Neuropathy (damage to nerves controlling muscles) look like?

The symptoms of motor neuron damage can vary depending upon the extent and location of the damage. Common signs include:

• muscle weakness
• twitching, cramps
• difficulty with movement or coordination
• difficulty with speaking, swallowing, or breathing.

In some cases, sensory function may also be affected.

Who gets Motor Neuropathy (damage to nerves controlling muscles)?

Certain cancer treatments can damage the nerves responsible for muscle movement and increase the risk of developing this condition.

Two classes of chemotherapy medications that have been linked to motor neuron damage are:

• the vinca alkaloids, most commonly Vincristine (Oncovin®)
• the taxanes, most commonly Paclitaxel (Taxol®)

How to prevent Motor Neuropathy (damage to nerves controlling muscles)

Preventing motor neuron damage in patients with cancer involves carefully managing cancer treatment and monitoring for any signs of nerve damage. Patients should be closely monitored for symptoms of nerve damage both during and after cancer treatment.

How to treat Motor Neuropathy (damage to nerves controlling muscles)

• If motor neuron damage is suspected, the causative agent is either temporarily or permanently discontinued.
• Treatment for motor neuron damage typically involves a combination of supportive care and symptom management such as:
  • physical therapy
  • occupational therapy
  • pain management
  • assistive devices to improve mobility and quality of life